Published on November 18, 2018 by the PALISADE Group of Clinical Investigators in the New England Journal of Medicine.
Once a peanut allergy develops, advice has historically been simple: lifelong complete avoidance is needed to prevent systemic allergic reactions, some of which could be fatal. However, over the past decade, a series of case reports and small studies have shown that the systematic introduction of tiny amounts of peanut allergen, followed by gradual increases in dose, could prevent or attenuate systemic reactions. The concept gained traction when a group in Cambridge, United Kingdom, found that 12% defatted peanut flour could induce desensitization in children.
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